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1
Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study.
PubMed Open HTML    
Eser D Rupprecht R  » 
Psychopharmacology (Berl) (2007) Show Abstract »
However, assessment of CCK-4-induced panic does not follow consistent rules.
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2
Severity of CCK-4-induced panic and anxiety, on the other hand was reduced by exercise.
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3
Effects of alprazolam on cholecystokinin-tetrapeptide-induced panic and hypothalamic-pituitary-adrenal-axis activity: a placebo-controlled study.
PubMed Open HTML    
Zwanzger P Rupprecht R  » 
Neuropsychopharmacology (2003) Show Abstract »
It has been shown that panic elicited by CCK-4 is improved after treatment with antidepressants.
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4
Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers.
PubMed Open HTML    
Maron E Shlik J  » 
Neurosci Lett (2008) Show Abstract »
Other polymorphisms previously associated with PD were unrelated to CCK-4-induced panic attacks, probably due to the differences between complex nature of PD and laboratory panic model.
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5
Panic induced by cholecystokinin tetrapeptide was significantly more pronounced in the short/short genotype subjects under escitalopram vs. placebo pre-treatment.
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6
Our results suggest that CCK-4-induced panic attacks are not suppressible by presynaptic alpha-2 receptor stimulation.
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7
CCK-4 induced a panic attack identical to spontaneous panic attacks in all patients; placebo did not induce any attacks.
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8
After pretreatment with ANP, the number of CCK-4-induced panic attacks decreased from 8 to 6 in patients and from 5 to 2 in controls.
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9
There was no significant difference between groups on the frequency of CCK-4-induced panic or the number and intensity of panic symptoms.
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10
Demonstrating that the effects of CCK-4 are reproducible in panic patients opens the doors for studies of the effects of drug treatment on CCK-4-induced panic.
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