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1
In conclusion, silymarin exerts beneficial effects on the early stages of liver pathogenesis, preventing and delaying liver carcinogenesis.
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2
In tumors, hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor protein levels were decreased by silibinin.
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3
Herein, we evaluated chemoprevention of urinary bladder cancer by natural chemopreventive agents, silymarin and silibinin, in a preclinical animal (ICR mouse) model of bladder cancer induced by tobacco smoke carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (OH-BBN).
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4
Further, silibinin modulates mitogenic and survival signalling, p53, Cip1/p21 and other cell cycle regulatory molecules to prevent UVB-induced skin carcinogenesis.
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5
These results, together with our other recent studies, suggest that silymarin could be useful in preventing a wide range of carcinogen and tumor promoter-induced cancers.
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6
Similarly, silymarin also prevented UVB-induced skin carcinogenesis.
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7
Together, these findings identify modulation of Rb levels and its phosphorylation status as a molecular mechanism of silibinin-induced neuroendocrine differentiation of human prostate carcinoma LNCaP cells and suggest that this could be a novel approach for prostate cancer prevention by silibinin.
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8
Together, these results identify distinct signaling pathways for the antiproliferative and apoptotic effects of silymarin and form a basis for developing strategies targeted to ERK and JNK pathways for the prevention and intervention of malignancies by silymarin.
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9
These findings suggest that silymarin is effective in preventing OH-BBN-induced bladder carcinogenesis in mice.
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10
Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft.
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Singh RP Agarwal R  » 
Carcinogenesis (2007) Show Abstract »
In established tumors, similar biomarkers and molecular changes were observed due to silibinin corresponding to its antitumor efficacy.
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