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1
Ciclosporin inhibits CYP3A, P-glycoprotein and OATP1B1.
2
CsA reduced renal blood flow, glomerular filtration rate, and kidney weight.
3 Full-text article
Cyclosporine inhibits NFAT binding to the P2 promoter of HNF4α.
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4
Cyclosporin A inhibited canine and murine keratinocyte proliferation, whereas cilomilast had no affect.
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5
However, in culture, CsA inhibits osteoclast differentiation and bone resorption.
6
Effect of cyclosporine on immune responses in submaxillary lymph nodes of pituitary-grafted rats.
PubMed Open HTML    
Arce A Esquifino AI  » 
Biol Signals (1996) Show Abstract »
In pituitary-grafted rats, cyclosporine decreased submaxillary lymph node LPS-induced proliferation.
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7
Cyclosporine-induced apoptosis in osteosarcoma cells.
PubMed Open HTML    
Oh YL Chang EJ  » 
Transplant Proc (2006) Show Abstract »
Pro-caspase-3 and Bcl-2 proteins were decreased by CsA.
8
Also, CsA and MeValCsA diminish cell death following cerebral ischemia, trauma, and hypoglycemia.
9
The mechanism of bone resorption by cyclosporin: involvement of the NO-cGMP pathway.
PubMed Open HTML    
Wimalawansa SM Wimalawansa SJ  » 
J Musculoskelet Neuronal Interact (2000) Show Abstract »
However, in vitro studies show that CsA inhibits bone resorption.
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10
Again, CsA suppressed seizure activity and reduced neuronal damage.
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