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1
Regulation of growth hormone receptors in human prostate cancer cell lines.
PubMed Open HTML    
Bidosee M Barkey RJ  » 
Mol Cell Endocrinol (2009) Show Abstract »
We now show that GH binding to GHR and GHR mRNA expression in the cell lines studied are hormonally regulated.
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2
Furthermore, receptor-selective variants of hGH that bind the hPRL receptor but not the hGH receptor were agonistic, providing additional support that specific binding to the hPRL receptor can stimulate these breast cancer cells to grow.
3 Full-text article
Angiotensin II upregulates the expression of placental growth factor in human vascular endothelial cells and smooth muscle cells
BioMed Central Open HTML Open PDF     PubMed Open HTML    
Pan P Liu X  » 
BMC Cell Biology (2010) Show Abstract »
It is a polypeptide growth hormone that binds to Flt-1-receptor (VEGFR-1), neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors, but not to VEGF-receptor type 2 (VEGFR-2).
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4 Full-text article
A Concerted Kinase Interplay Identifies PPARγ as a Molecular Target of Ghrelin Signaling in Macrophages
PubMed Central Open HTML Open PDF     PubMed Open HTML    
Demers A Tremblay A  » 
PLoS One (2009) Show Abstract »
We recently reported that a growth hormone secretagogue which interacts with both the GHS-R1a receptor and the scavenger receptor CD36 markedly decreased plaque formation in apoE-null mice fed a high fat diet, a condition known to promote atherosclerosis , .
5
DEX decreased GH binding to a GHR mutant F346A, which is reported to be deficient in ligand-induced internalization, suggesting that DEX decreases GH binding by a mechanism distinct from that of ligand-induced GHR internalization.
6
The human growth hormone antagonist B2036 does not interact with the prolactin receptor.
PubMed Open HTML    
Goffin V Kelly PA  » 
Endocrinology (1999) Show Abstract »
Human GH is also able to bind to the receptor of prolactin (PRLR).
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7
We hypothesized that the decrease in GHR 1A mRNA at parturition was associated with decreased GH binding (i.e., GHR protein concentration) in liver.
8
Three patients developed serum antibodies to GH with a binding capacity greater than 0.02 mg/l, but in only one patient was the GH binding capacity greater than 1.0 mg/l and he showed no attenuation of growth response.
9
Ovine (o) PRL, bovine (b) GH, or human (h) GH were introduced after 2-4 days of culture, and PRL receptors were measured by determining [125I]hGH binding in the presence and absence of excess oPRL in a total particulate fraction pretreated with 3 M MgCl2.
10
Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C.
PubMed Open HTML    
Falls HD Kaszubska W  » 
J Mol Endocrinol (2006) Show Abstract »
In this context, GHS-R has been recognized as a potential target for the treatment of GH deficiency and body weight disorders.
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