Quertle® - Intelligent semantic queries of MEDLINE (PubMed) and the biomedical literature

Why Quertle is Different

It's easy - Quertle's friendly interface makes it simple to search and refine results.
It's powerful - Using its advanced semantics, Quertle finds quality search results, not just long lists.
It's inclusive - All of PubMed (MEDLINE) plus an ever increasing number of full-text documents.
NEW: More Content - News (so you can find information before publication in the literature) and whitepapers (corporate
research reports and scientific posters).

Find Relationships, not Just Keywords

If you search for two or more terms, you will find occurrences of a conceptual relationship, not just the terms scattered within the same document.

Focus on Core Concepts

Since Quertle searches for Relationships, all the terms in your query must be found together in a meaningful way. Thus, Quertle immediately gives you results with more relevance.

Unleash the Strength of Power Terms™

Use Power Terms to search for categories of objects. For instance, you can use "$Protein" to search for any protein, rather than the occurrence of the term, "protein". View all Power Terms.

Search Full-text Documents

The Quertle search engine has been optimized to search full-text documents, including the Material and Methods section (but not the Bibliography).

Use Real Biology & Chemistry Terms

Quertle recognizes capital "TWIST" as the transcription factor (not the verb), and capital "NO" as "nitrous oxide"(not a negative). So, use proper capitalization in your query, and you won't be lost in a sea of irrelevant results.

Look for the Quertle Difference on the Results Page

» More relevant results

» Easy filtering and breadcrumb tracking

» Automatic identification of key concepts

» Single-click access to PDFs of full-text documents

Quertle is a registered trademark of Quertle, LLC. PubMed & MEDLINE are registered trademarks of the National Library of Medicine.

Power Terms™

Use any of the following Power Terms in your query to represent an entire class of related concepts. Click on a term to add it to the current query (or type them directly). Power Terms can be combined in a single query. The most common Power Terms are shown below; for more, see the full list of Power Terms.

$Genes

any gene or gene product such as BRCA2 or p53, but not the word "gene".

Example: HDAC1 regulates what genes

$Proteins

any gene product PLUS multimeric proteins such as FSH or AP-1, but not the word "protein".

Examples: $Proteins regulate apoptosis

$Chemicals

any chemical or drug, such as trichloroethene or Aricept. This class includes antibodies used as drugs.

Example: $Chemicals treat migraine

$Organisms

all living things.

Example: $Organisms produce methane

$Diseases

any disease.

Example: ethanol causes $Diseases

$CellTypes

any cell type, such as macrophages and neurons.

Example: ethanol affects $CellTypes

$AdverseEffects

side effects, ranging from the molecular level (e.g., mutation) to diseases.

Example: ethanol causes $AdverseEffects

$Biomarkers

Proteins, metabolites, etc. associated with a process or disease as noted in the literature.

Example: $Biomarkers blood cancer (to show those markers associated with blood cancers

Full List of Power Terms

Examples

Sample queries for several fields are shown. Click the desired query to execute any of the samples.

Molecular Biology Examples

p53 pRB - looking for relationships between these proteins

p53 binds MDM2 - looking specifically for papers that have the concept "MDM2 binds p53" - not simply papers that include all three terms

cell cycle - looking for information about this process

$Proteins regulate cell cycle - using a Power Term™ to find what proteins regulate the cell cycle

Medicine Examples

what causes diabetes - looking for all concepts that may be associated with the cause of diabetes

$Chemicals cause diabetes - using a Power Term to specifically find small molecules that may cause diabetes

Toxicology Example

arsenic $Diseases - looking for diseases that are associated with arsenic

Neuroscience Examples

neurotransmitter - looking for literature on this class of compounds

what neurotransmitters affect epilepsy - looking for specific neurotransmitters involved in this disease

Chemistry Examples

polyphenols - looking for literature on this class of compounds

$Chemicals react with glutathione - using a Power Term to specifically find small molecules that react with glutathione

Cell Biology Examples

Golgi apparatus - looking for literature on this cell component

mitochondria regulation - looking for concepts associated with mitochondrial regulation


	Quertle searches for relationships. Thus, it is best to focus your initial query on the core concepts of interest. Then, add additional terms (and dates) when you filter the results. Authors and journals should be entered into their own search boxes. Example use this: caffeine treats migraines instead of this: caffeine treats migraines in mice 2009 Smith Start typing a name to display a list of authors. As you type more, the list will update accordingly. When you see the author you want, select that name from the list. Separate multiple authors by a comma. If more than one author is entered, the results must contain ALL of the names. Start typing to display a list of journals. As you type more, the list will update accordingly. When you see the journal you want, select it from the list. Separate multiple journals by a comma. The results will be for ANY of the entered publications. This tab displays documents containing relationships that match your query. As you filter the results, the number will update. This tab displays documents simply containing your search terms, not necessarily in a meaningful relationship. As you filter the results, the number will update. To remove any filter, click its . When multiple filters are applied, all can be removed using the that appears next to this hint. Or, click on any of the filters to remove all filters below that level. Relationships: Filter relationships to those that contain an additional term within the actual relationship. Keyword Results: Filter documents to those that contain the additional term anywhere within the searched text. Key Concepts related to your query will appear in this list. If you used a Power Term™, the members of that class of objects appearing in the relationships will be shown. If other terms in your query represent a group of entities (such as "neurotransmitters"), these may be also be listed in separate sections. If your query contains the term "what" (for example, "what controls cell cycle"), the first set of terms listed are specifically from the portion of the relationship that might contain the "what". All queries will also have a section called "General Concepts". These are additional concepts that may be of interest. Click on a term to display only those results that contain the concept of interest. The listed concepts are based on a statistical sampling and are not all-inclusive.

Quertle: Relationship-Driven Biomedical Search

Why Quertle is Different

Find Relationships, not Just Keywords

Focus on Core Concepts

Unleash the Strength of Power Terms™

Search Full-text Documents

Use Real Biology & Chemistry Terms

Look for the Quertle Difference on the Results Page

Relationships vs. Keywords

Results Order

Easy to Use Filters

Key Concepts

Highlighting

Power Terms™

Examples