Quertle® - Intelligent semantic queries of MEDLINE (PubMed) and the biomedical literature

Power Terms™ Use any of the following Power Terms in your query to represent an entire class of related concepts. Click on a term to add it to the current query (or type them directly). Power Terms can be combined in a single query. The most common Power Terms are shown below; for more, see the full list of Power Terms.
$Genes any gene or gene product such as BRCA2 or p53, but not the word "gene". Example: EGFR regulates $Genes $Proteins any gene product PLUS multimeric proteins such as FSH or AP-1, but not the word "protein". Example: What $Proteins affect Treg? $Chemicals any chemical or drug, such as trichloroethene or Aricept. This class includes antibodies used as drugs. Example: $Chemicals affect T-Helper cells $Organisms all living things. Example: $Organisms produce methane	$Diseases any disease. Example: VEGF affects $Diseases $CellTypes any cell type, such as macrophages and neurons. Example: ethanol affects $CellTypes $AdverseEffects common side effects, ranging from the molecular level (e.g., mutation) to diseases. Example: ethanol causes $AdverseEffects $Biomarkers Sponsored by: SciWit: Analysis Experts Proteins, metabolites, etc. associated with a process or disease as noted in the literature. Example: $Biomarkers blood cancer
Full List of Power Terms

Examples

Sample queries for several fields are shown. Click the desired query to execute any of the samples. Note that queries are focused on Relationships, leaving modifier terms to be applied as filters.

Molecular Biology Examples

p53 Bax - looking for relationships between these proteins

p53 $PositiveActions Foxp3 - looking specifically for papers that have the concept "p53 has a positive effect on Foxp3" - not simply papers that include the terms

cell cycle - looking for information about this process

$Proteins regulate mitosis - using a Power Term™ to find what proteins regulate mitosis

Medicine Examples

what causes diabetes - looking for all concepts that may be associated with the cause of diabetes

$Chemicals cause diabetes - using a Power Term to specifically find small molecules that may cause of diabetes

VWF affects $Diseases - using a Power Term to find diseases realted to the VWF gene

Toxicology Example

arsenic $Diseases - looking for diseases that are associated with arsenic

Immunology Examples

cytokine immune response - looking for information on the effect of cytokines on immune response

Neuroscience Examples

neurotransmitter - looking for literature on this class of compounds

what neurotransmitters affect epilepsy - looking for specific neurotransmitters involved in this disease

Chemistry Examples

polyphenols - looking for literature on this class of compounds

$Chemicals react with glutathione - using a Power Term to specifically find small molecules that react with glutathione

Cell Biology Examples

Golgi apparatus - looking for literature on this cell component

mitochondria regulation - looking for concepts associated with mitochondrial regulation

Methods Examples

fluorochromes - looking for literature on the use of these agents

antibodies flow cytometry - looking for literature on the use of antibodies in flow cytometry

Quertle: Relationship-Driven Biomedical Search

Why Quertle

How to Quertle

Follow Quertle


	To find the most focused results, Quertle searches for assertions made by the author(s) that tie all of your search terms together in a meaningful way. Thus, it is best to focus your initial query on the core concepts of interest, such as "what causes B". Then, add additional terms, such as "mice", and dates when you filter the results. Authors and journals should be entered into their own search boxes. Example use this: caffeine treats migraines instead of this: caffeine treats migraines in mice 2009 Smith As you type, automatic suggestions will appear. Click on a suggestion to run that search. Or, use the arrow keys to select a search and then keep typing to add additional terms. Start typing a name to display a list of authors. As you type more, the list will update accordingly. When you see the author you want, select that name from the list. Separate multiple authors by a comma. If more than one author is entered, the results must contain ALL of the names. Start typing to display a list of journals. As you type more, the list will update accordingly. When you see the journal you want, select it from the list. Separate multiple journals by a comma. The results will be for ANY of the entered publications. This tab displays documents where the author(s) made a statement connecting your search terms together in a meaningful way. As you filter the results, the number will update. This tab displays the broader set of documents that contain your all of search terms anywhere in the text. As you filter the results, the number will update. To remove any filter, click its . When multiple filters are applied, all can be removed using the that appears next to this hint. Or, click on any of the filters to remove all filters below that level. If your organizational affiliation has been automatically recognized, it will be displayed. Otherwise, Log in to MyQuertle to choose your organization. Please Log in to MyQuertle to choose your organization. Your organization has not yet signed up for free linking to Quertle. Ask your librarian to request a connection. Filter documents to those that contain the additional term anywhere within the relevant text including the title, abstract, body (for full-text), MeSH terms, and chemical list. Key Concepts related to your query will appear in this list. If you used a Power Term™, the members of that class of objects appearing in the relevant author statements will be shown. If other terms in your query represent a group of entities (such as the automatic Power Term "neurotransmitters"), these may be also be listed in separate sections. If your query contains the term "what" (for example, "what controls cell cycle"), the first set of terms listed are specifically from the portion of the relationship that might contain the "what". All queries will also have a section called "General Concepts". These are additional concepts that may be of interest. Click on a term to display only those results that contain the concept of interest. The listed concepts are derived from the most relevant results. Log in to MyQuertle to save this search. You have saved the maximum number of searches. Review your saved searches here. Click here to add the current search along with all applied filters to your MyQuertle Saved Searches. The current search along with all applied filters has been added to or already exists in your MyQuertle Saved Searches. Save searches, link to your organization's library subscriptions, choose preferences. View saved searches including the applied filters. Update your profile, including email and institution. Set optional user preferences here. Each row contains the search and applied filters you saved. Click the button to rerun the search in that row. Check the box in this column to receive a weekly Alert for new documents that meet your search criteria. Click the to remove the corresponding search from your saved search list. Good diabetes leukemia Bad diabetes leukemia review Schmidt 2012 (Authors go in the Author box; use the filters for Publication Type & Date) Using a Power Term in your query will find all members of that class, but not the term itself. For example, the $Diseases Power Term will find "diabetes", "COPD", and other diseases, but not "disease", "syndrome", etc. p53 $Proteins - will find documents connecting p53 with any other protein, answering the question "what other protiens might be in a network with p53 benzidine $Diseases - will find documents that connect benzidine to any disease, answering the question "what diseases are associated with benzidine" $ProteinKinases control cell cycle - will find documents where any protein kinase controls cell cycle, answering the question "what protein kinases are involved in controlling the cell cycle See the full list of Power Terms. Many terms - such as NO (nitric oxide) and no (the negative) - are clearly different depending an capitalization. So use the proper case to indicate what you mean. If you use the spelled out form for a term, Quertle will be able to find statements where the term is abbreviated. For example a search for norepinephrine will find NE, when it actually means norepinephrine. But a search for NE will find not only norepinephrine, but also northeast, negative emotionality, neurological examination, and many, many more. Quertle searches for assertions made by the authors. Actions (that is, verbs) are cntral to those assertions. So,using a verb in your query will go a long way toward getting focused results. p53 binds BAX - will find documents where p53 binds to BAX, as opposed to other reasons the two proteins are mentioned together PGE2 activates what - will find documents where PGE2 activates something, as opposed to any mention of PGE2